Sedation and Analgesia for Toxic Epidermal Necrolysis in the Intensive Care Unit: Few Certainties, Many Questions Ahead

Analgesia and sedation in intensive care unit.

BACKGROUND AND OBJECTIVES Many Intensive Care Unit (ICU) patients present pain. The administration of analgesics and sedatives is crucial for patient comfort and to reduce stress, as well as to prevent delay in recovery and ventilator weaning. The objective of the present study was to conduct a review on analgesia and sedation in the ICU. CONTENT The present study reviewed the causes of pain,...

Remifentanil for analgesia-based sedation in the intensive care unit

Providing effective analgesia and adequate sedation is a generally accepted goal of intensive care medicine. Due to its rapid, organ independent and predictable metabolism the short acting opioid remifentanil might be particularly useful for analgesia-based sedation in the intensive care unit (ICU). This hypothesis was tested by two studies in this issue of Critical Care. The study by Breen et ...

Sedation, analgesia, and paralysis in the intensive care unit.

Intensive Care in a Patient with Toxic Epidermal Necrolysis

Toxic epidermal necrolysis (TEN) is a serious adverse drug reaction with high lethality, which usually requires intensive-medical care. A 44-year-old man developed generalized exanthema with increasing exfoliation and mucosal involvement after taking allopurinol, ibuprofen, and etoricoxib. The clinical diagnosis of TEN was histologically confirmed. Prednisolone therapy with 3 mg/kg body weight ...

Diet and pancreatic cancer: many questions with few certainties.

UNLABELLED BACKGROUND, OBJECTIVES: Pancreatic cancer ranks fourth for cancer mortality for men and women in the United States. This is a particularly devastating cancer since the case-fatality proportion approaches 90% within 12 months following diagnosis. Therefore, understanding the etiology and identifying the risk factors are essential for the primary prevention of this deadly disease. Of t...